Without seeing any cases in the past 15 years, over the past couple of months I’ve seen two cases of agenesis of the corpus callosum.
The first case is a middle-aged man with moderate intellectual challenges who drowned while swimming in a lake. Here’s a picture of the brain after fixation:
The second case was a very young infant who died at home in the context of possible unsafe sleeping conditions. This is a photo of unfixed brain. I did not suspect this lesion, and didn’t notice it until I had already prosected and discarded the cerebellum and brainstem.
Agenesis of the corpus callosum has variable symptoms. In newborns, it is associated with other genetic issues in about 70% of cases. People with this abnormality are at a higher rate of seizures, which is of importance both to sudden infant death and drowning.