{"id":633,"date":"2020-10-24T22:55:01","date_gmt":"2020-10-25T02:55:01","guid":{"rendered":"http:\/\/wordpress.forensicpath.us\/?p=633"},"modified":"2023-11-24T21:36:48","modified_gmt":"2023-11-25T02:36:48","slug":"pathology-cases-focal-hepatocellular-necrosis","status":"publish","type":"post","link":"https:\/\/wordpress.forensicpath.us\/index.php\/2020\/10\/24\/pathology-cases-focal-hepatocellular-necrosis\/","title":{"rendered":"Pathology cases — Focal hepatocellular necrosis"},"content":{"rendered":"

These are just a few nice examples of focal hepatocellular necrosis in a decedent with a history of hepatitis C and intravenous drug use.<\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

As always, free for use in lectures and teaching, etc. with or without attribution, though attribution is always appreciated.\u00a0 These are slightly reduced resolution images.\u00a0 If you need original resolution images, contact me.<\/p>\n

Update:\u00a0 One correspondent suggested that this may be better considered something like lobular inflammation in nonspecific reactive hepatitis.\u00a0 That’s a good criticism.\u00a0 \u00a0 My response was:<\/p>\n

‘Sure. \u00a0Without the history, that’s what this guy would have had — though I usually just say “hepatitis” and move on. \u00a0Focal hepatocellular necrosis is one of the components of it. \u00a0One old article that comes up on a search states:<\/div>\n
<\/div>\n
“Nonspecific reactive hepatitis represents a group of abnormal histological findings including ductular proliferation, portal and periportal inflammatory infiltration, focal necrosis, Kupffer cell mobilization, and evidence of regeneration…”<\/i><\/div>\n
<\/div>\n
Schaffner F, Popper H. Nonspecific reactive hepatitis in aged and infirm people. \u00a0Am J Digestive Dis. 1959 4:389-399.<\/div>\n
<\/div>\n
A couple of sources (for instance, Sanjay Kakar in the book “Liver Pathology” \u00a0 2011 Demos Medical Publishing) says you can, but don’t necessarily see focal necrosis in nonspecific reactive hepatitis. \u00a0Instead, he focuses on “lobular inflammation.” \u00a0My impression, which could easily be wrong, is that if you don’t see dead liver cells, it’s “lobular inflammation,” and if you do see dead liver cells, it’s “focal hepatocellular necrosis.” \u00a0I thought I saw some dead hepatocytes in them thar hills, so I ran with the latter.’<\/div>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

These are just a few nice examples of focal hepatocellular necrosis in a decedent with a history of hepatitis C…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[109,60,1],"tags":[59,80,56,75,25,28,26],"class_list":["post-633","post","type-post","status-publish","format-standard","hentry","category-pathology-cases","category-photomicrographs","category-uncategorized","tag-autopsy","tag-focal-hepatocellular-necrosis","tag-histology","tag-liver","tag-microscopy","tag-pathology","tag-photomicrography"],"_links":{"self":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts\/633","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/comments?post=633"}],"version-history":[{"count":5,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts\/633\/revisions"}],"predecessor-version":[{"id":649,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts\/633\/revisions\/649"}],"wp:attachment":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/media?parent=633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/categories?post=633"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/tags?post=633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}