{"id":2117,"date":"2024-11-01T12:20:47","date_gmt":"2024-11-01T16:20:47","guid":{"rendered":"https:\/\/wordpress.forensicpath.us\/?p=2117"},"modified":"2024-11-01T12:36:15","modified_gmt":"2024-11-01T16:36:15","slug":"pathology-cases-diffuse-pulmonary-ossification","status":"publish","type":"post","link":"https:\/\/wordpress.forensicpath.us\/index.php\/2024\/11\/01\/pathology-cases-diffuse-pulmonary-ossification\/","title":{"rendered":"Pathology cases: Diffuse pulmonary ossification"},"content":{"rendered":"

A 78-year-old man with a complex medical history based primarily in obesity and metabolic syndrome was found dead in bed.\u00a0 He was brought in because of allegations of elder abuse.\u00a0 Autopsy confirmed his multiple comorbidities and no injuries.\u00a0 In addition, his lungs were somewhat firm, resistant to the knife, and very “gritty” when palpated.<\/p>\n

On histology, many of his alveoli were filled with ectopic bone.\u00a0 Ectopic bone formation in the lung is uncommon and is usually asymptomatic, though it can present with symptoms similar to interstitial lung disease.\u00a0 It comes in two types, “dendritic” in which there are branching tree-like shape in small airways, and “nodular” in which small fragments of bone are usually found in alveoli.\u00a0 This is an example of diffuse nodular pulmonary ossification.<\/p>\n

Pulmonary ossification can be ideopathic or secondary.\u00a0 Ideopathic cases are more often associated with inflammation.\u00a0 Secondary pulmonary ossification is associated with a myriad of diseases.\u00a0 I don’t understand the mechanics of the pathogenesis, though it’s easy to speculate on minor injury plus calcium metabolism problems.\u00a0 But I don’t know.<\/p>\n

Here’s a panorama of the whole section.\u00a0 You can see the fragments of bone as dark pink objects.\u00a0 In the second image, the more prominent collections are circled:<\/p>\n

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Here are some higher magnification images:<\/p>\n

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As always, these images are free to use with or without attribution, though attribution is appreciated.\u00a0 Higher resolution images are available if you contact me.<\/p>\n","protected":false},"excerpt":{"rendered":"

A 78-year-old man with a complex medical history based primarily in obesity and metabolic syndrome was found dead in bed.\u00a0…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[109,60,1],"tags":[59,65,26],"class_list":["post-2117","post","type-post","status-publish","format-standard","hentry","category-pathology-cases","category-photomicrographs","category-uncategorized","tag-autopsy","tag-lung","tag-photomicrography"],"_links":{"self":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts\/2117","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/comments?post=2117"}],"version-history":[{"count":5,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts\/2117\/revisions"}],"predecessor-version":[{"id":2129,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts\/2117\/revisions\/2129"}],"wp:attachment":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/media?parent=2117"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/categories?post=2117"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/tags?post=2117"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}