{"id":1928,"date":"2024-09-29T23:16:00","date_gmt":"2024-09-30T03:16:00","guid":{"rendered":"https:\/\/wordpress.forensicpath.us\/?p=1928"},"modified":"2024-09-29T23:16:00","modified_gmt":"2024-09-30T03:16:00","slug":"pathology-cases-hurthle-cell-transformation-in-a-thyroid","status":"publish","type":"post","link":"https:\/\/wordpress.forensicpath.us\/index.php\/2024\/09\/29\/pathology-cases-hurthle-cell-transformation-in-a-thyroid\/","title":{"rendered":"Pathology cases — Hurthle cell transformation in a thyroid"},"content":{"rendered":"

This is from a 60 year old woman who died of a drug overdose.\u00a0 At autopsy her thyroid was a little small but pale and firm.\u00a0 On histology, there is a prominent lymphocytic thyroiditis.\u00a0 Within the areas of inflammation are enlarged eosiniphilic cells, called Hurthle cells.<\/p>\n

Here is a low power view.\u00a0 The darker blue areas are aggregates of lymphocytes.\"\"<\/a><\/p>\n

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Here are medium power views.\u00a0 You can see within the collections of lymphocytes there are clumps of pink cells.\u00a0 You can see the smaller normal follicular epithelial cells at the edge of the images.<\/p>\n

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 <\/p>\n

And a high power view:<\/p>\n

\"\"<\/a> \"\"<\/a><\/p>\n

Hurthle cells are big and eosinophilic because they are filled with mitochondria.\u00a0 They are characteristic of Hashimoto’s thyroiditis, but can arise as independent benign and malignant neoplasms.<\/p>\n

You’ll note that I called this a “lymphocytic thyroiditis” rather than “Hashimoto’s thyroiditis” because I was trained that you couldn’t call it Hashimoto’s unless you saw Hurthle cells *and* germinal centers, and I didn’t see any good germinal centers in this slide.<\/p>\n

As always, free for use in lectures, etc. with or without attribution — though attribution is appreciated.\u00a0 If you need a higher resolution image, contact me.<\/p>\n","protected":false},"excerpt":{"rendered":"

This is from a 60 year old woman who died of a drug overdose.\u00a0 At autopsy her thyroid was a…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[109,60],"tags":[56,28,111],"class_list":["post-1928","post","type-post","status-publish","format-standard","hentry","category-pathology-cases","category-photomicrographs","tag-histology","tag-pathology","tag-thyroid"],"_links":{"self":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts\/1928","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/comments?post=1928"}],"version-history":[{"count":1,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts\/1928\/revisions"}],"predecessor-version":[{"id":1938,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts\/1928\/revisions\/1938"}],"wp:attachment":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/media?parent=1928"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/categories?post=1928"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/tags?post=1928"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}