{"id":1781,"date":"2024-05-01T11:15:13","date_gmt":"2024-05-01T15:15:13","guid":{"rendered":"http:\/\/wordpress.forensicpath.us\/?p=1781"},"modified":"2024-05-13T21:40:38","modified_gmt":"2024-05-14T01:40:38","slug":"is-this-an-artifact","status":"publish","type":"post","link":"https:\/\/wordpress.forensicpath.us\/index.php\/2024\/05\/01\/is-this-an-artifact\/","title":{"rendered":"Pathology cases &#8211; Mitochondrial calcification in a cardiac microinfarction"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>This case was originally posted as an unknown.\u00a0 The consensus of folk who got back to me is that this is an uncommon degenerative process in a microinfarction where the mitochondria calcify, leading to the appearance of multiple faint blue dots in an area of myocyte necrosis.\u00a0 Apparently it is more commonly seen in microinfarctions associated with catecholamines (e.g. stress cardiomyopathy, ingestion of sympathomimetics such as methamphetamine).<\/p>\n<p>This is the case of a teenager found dead in bed in the morning.\u00a0 He had been complaining of a URI the evening before.\u00a0 At autopsy, he doesn&#8217;t have much going on.\u00a0 A little pulmonary edema R&amp;L lungs 710 and 530 grams),\u00a0 \u00a0The heart was a little big at 430 grams with mild LV dilation.\u00a0 Tox is negative. Viral culture positive for rhinovirus.\u00a0 Bacterial cultures were taken at three locations (first hospital, referral hospital, ME office).\u00a0 All three were positive, but all three grew multiple different organisms, with no overlap between labs.<\/p>\n<p>At autopsy, he had one odd finding &#8212; these areas in the myocardium.\u00a0 I usually take 8 sections of heart (posterior lv, lateral lv, anterior lv, ivs, rv, avn, san x2).\u00a0 These areas were sparsely found in all of the LV sections.<\/p>\n<p>Here&#8217;s an overview:<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5923.out-DSC_5969.out_.scaled-scaled.webp\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-large wp-image-1784\" src=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5923.out-DSC_5969.out_.scaled-1024x876.webp\" alt=\"\" width=\"688\" height=\"589\" srcset=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5923.out-DSC_5969.out_.scaled-1024x876.webp 1024w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5923.out-DSC_5969.out_.scaled-300x256.webp 300w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5923.out-DSC_5969.out_.scaled-768x657.webp 768w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5923.out-DSC_5969.out_.scaled-1536x1313.webp 1536w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5923.out-DSC_5969.out_.scaled-2048x1751.webp 2048w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5923.out-DSC_5969.out_.scaled-1600x1368.webp 1600w\" sizes=\"(max-width: 688px) 100vw, 688px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Here&#8217;s a closeup of one area:<\/p>\n<p><a href=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/cropped.webp\"><img decoding=\"async\" class=\"alignnone size-full wp-image-1786\" src=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/cropped.webp\" alt=\"\" width=\"1000\" height=\"598\" srcset=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/cropped.webp 1000w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/cropped-300x179.webp 300w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/cropped-768x459.webp 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/a><\/p>\n<p>Here&#8217;s a GMS:<\/p>\n<p><a href=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5973.out_-scaled.jpg\"><img decoding=\"async\" class=\"alignnone size-large wp-image-1782\" src=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5973.out_-1024x683.jpg\" alt=\"\" width=\"688\" height=\"459\" srcset=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5973.out_-1024x683.jpg 1024w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5973.out_-300x200.jpg 300w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5973.out_-768x512.jpg 768w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5973.out_-1536x1024.jpg 1536w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5973.out_-2048x1366.jpg 2048w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5973.out_-1600x1067.jpg 1600w\" sizes=\"(max-width: 688px) 100vw, 688px\" \/><\/a><\/p>\n<p>Here&#8217;s Gram:<\/p>\n<p><a href=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5975.out_-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-1785\" src=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5975.out_-1024x683.jpg\" alt=\"\" width=\"688\" height=\"459\" srcset=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5975.out_-1024x683.jpg 1024w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5975.out_-300x200.jpg 300w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5975.out_-768x512.jpg 768w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5975.out_-1536x1024.jpg 1536w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5975.out_-2048x1366.jpg 2048w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5975.out_-1600x1067.jpg 1600w\" sizes=\"(max-width: 688px) 100vw, 688px\" \/><\/a><\/p>\n<p>Here&#8217;s trichrome:<\/p>\n<p><a href=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5971.out_-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-1783\" src=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5971.out_-1024x683.jpg\" alt=\"\" width=\"688\" height=\"459\" srcset=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5971.out_-1024x683.jpg 1024w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5971.out_-300x200.jpg 300w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5971.out_-768x512.jpg 768w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5971.out_-1536x1024.jpg 1536w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5971.out_-2048x1366.jpg 2048w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5971.out_-1600x1067.jpg 1600w\" sizes=\"(max-width: 688px) 100vw, 688px\" \/><\/a><\/p>\n<p>It&#8217;s not a yeast like .\u00a0 I thought for a minute it might be trympanosomiasis, but it really doesn&#8217;t look like Chaga&#8217;s disease either (those bugs tend to be in mini intracellular cysts).\u00a0 \u00a0But I have never had a case of Chaga&#8217;s disease, so I don&#8217;t have experience to fall back on, and I don&#8217;t feel confident in ruling it out.\u00a0 Unfortunately, the lab we use found my postmortem specimen to be unsuitable for antibody testing (as so often happens with postmortem testing).\u00a0 Is this just some sort of degeneration artifact?<\/p>\n<p>I found one small area in the myocardium with lymphocytes:<\/p>\n<p><a href=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5917.out_-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-1787\" src=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5917.out_-1024x683.jpg\" alt=\"\" width=\"688\" height=\"459\" srcset=\"https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5917.out_-1024x683.jpg 1024w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5917.out_-300x200.jpg 300w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5917.out_-768x512.jpg 768w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5917.out_-1536x1024.jpg 1536w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5917.out_-2048x1366.jpg 2048w, https:\/\/wordpress.forensicpath.us\/wp-content\/uploads\/2024\/05\/DSC_5917.out_-1600x1067.jpg 1600w\" sizes=\"(max-width: 688px) 100vw, 688px\" \/><\/a><\/p>\n<p>After hearing from commenters and folk on a mailinglist, it seems this is a microinfarction with a somewhat unusual pattern of karrhyorexis.\u00a0 Even though this is more commonly seen in catecholamine exposure, there was no history of drug use, and toxicologic evaluation was negative.\u00a0 In the presence of a URI and positive viral cultures, I ended up diagnosing viral myocarditis, even though I would have preferred to see more inflammation.\u00a0 It&#8217;s as much a diagnosis of exclusion as anything else.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; This case was originally posted as an unknown.\u00a0 The consensus of folk who got back to me is that&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[109,60],"tags":[66,56,28],"class_list":["post-1781","post","type-post","status-publish","format-standard","hentry","category-pathology-cases","category-photomicrographs","tag-heart","tag-histology","tag-pathology"],"_links":{"self":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts\/1781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/comments?post=1781"}],"version-history":[{"count":4,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts\/1781\/revisions"}],"predecessor-version":[{"id":1804,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/posts\/1781\/revisions\/1804"}],"wp:attachment":[{"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/media?parent=1781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/categories?post=1781"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wordpress.forensicpath.us\/index.php\/wp-json\/wp\/v2\/tags?post=1781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}